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Abstract

Background

This is an open-label, randomised controlled trial. The primary outcome was the change from baseline in ED medication (Viagra® and Cialis®) and total medication doses (Viagra® and Cialis®) on randomisation (Rx). The secondary outcomes were the change from baseline in ED medication (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) on Rx. The primary outcomes were changes from baseline in ED medication (Viagra® and Cialis®) and total medication doses (Viagra® and Cialis®) on randomisation (Rx).

Methods

Study Population

A total of 999 patients were randomised (in 2, 3 or 4 groups) to either sildenafil (Viagra® and Cialis®) or placebo (placebo). The randomisation groups were double-blinded for one month. At the end of treatment, patients were assessed at 1, 4, and 12 months. The primary outcome was the change from baseline in total medication doses (Viagra® and Cialis®) and total medication doses (Viagra® and Cialis®) on randomisation (Rx). The secondary outcomes were the change from baseline in total medication doses (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) on Rx. There were 10 Rx in the placebo group and 5 Rx in the sildenafil group (at randomisation).

Clinical Questionnaire

Patients were given a 12-lead telephone questionnaire, which was completed by all patients and assessed at the baseline ( baseline, at baseline, and at 1 and 4 months) and at the 2, 3, and 4 months. The patients completed the questionnaire at each month. All patients were asked to complete the following questionnaires:

Question 1:“Have you ever had erectile dysfunction in the last 12 months?”

Question 2:

Question 3:“Are you currently having any sexual activity and is it a routine activity?”

Question 4:“Are you currently using any form of phosphodiesterase type 5 (PDE5) inhibitor or currently using any form of phosphodiesterase type 5 (PDE5) inhibitor and are you on any other medications?”

The questionnaires were repeated at each month. The final questionnaires were completed in two-steps (1 and 2 steps) by all patients (in 2 steps).

Intervention

Randomised 1-arm (in 2 steps) double-blinded for one month and randomised for 2 months. The trial protocol was registered with the Clinical Trial Registry for the Protection against Medicines. In each arm, two patients were given placebo (sildenafil) or Viagra® (Cialis®) and were also given an alternative treatment to Cialis®. The primary outcome was the change from baseline in ED medication (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) on Rx. The secondary outcomes were the change from baseline in ED medication (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) and the change from baseline in total medication doses (Viagra® and Cialis®) on Rx. Patients were given a single dose of each medication to which they were taking sildenafil and a single dose of placebo.

Intervention 1

Randomised to sildenafil or placebo, patients in randomised to one of two treatment arms, either sildenafil or placebo.

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Your daily dosage will depend on your medical condition, how you respond to medications, and any other medications you currently take. Before you take ED treatment pills, ensure that you inform your healthcare service provider of any prescription drugs, over-the-counter medicines, and any other supplements you take.

If you are also using finasteride alongside Tadalafil to treat any symptoms of benign prostatic hyperplasia (BPH), discuss the duration of treatment and dosage you will need with your healthcare provider.

For erectile dysfunction (ED), tadalafil citrate may be prescribed in two ways:

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  • Your doctor may recommend taking generic Cialis regularly, once a day.

Follow your doctors instructions carefully based on your specific needs and condition.

If you are using tadalafil citrate medication for ED dysfunction and BPH, take it daily as directed by your doctor. To ensure you do not forget, take it at the same time each day.

Keep your healthcare practitioner informed if your medical condition does not improve or worsens during treatment.

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A recent survey of pharmacists in the Philippines revealed that a large number of women in their 30s and 40s are taking PDE5 inhibitors, including Viagra. While Viagra may have helped them avoid erectile dysfunction by allowing them to obtain and maintain an erection, the drugs do not provide any immediate benefit, and there is a long list of other ED drugs available on the market, such as Cialis.

Cialis is a prescription medication used to treat erectile dysfunction. The FDA has approved it in the U. S. under the brand name Cialis, and it is not currently available in Canada. A survey of pharmacists in the Philippines by the University of the Philippines found that only a small percentage of them were able to purchase the drug. While it is possible that Cialis will be approved soon, it is still a prescription medication and will be necessary to obtain it.

It is important for those with erectile dysfunction to have a medical check-up to make sure that there is no underlying health problem, and to be aware of potential side effects and to be aware of any drug interactions. Many women taking the drug do not experience any side effects and it is important to seek medical advice before taking the drug.

If you are a candidate for the drug, the information provided on the website may not be accurate. It is recommended that you do not take the drug if you have a history of stomach problems, liver disease, kidney disease or heart failure.

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